Olivier Dulac Selected Research

Vigabatrin

1/2020	Are Epileptic Spasms a Seizure Type for the Insular Region?
1/2019	Pharmacokinetic evaluation of vigabatrin dose for the treatment of refractory focal seizures in children using adult and pediatric data.
1/2019	Proposition of a Minimal Effective Dose of Vigabatrin for the Treatment of Infantile Spasms Using Pediatric and Adult Pharmacokinetic Data.
4/2016	Epilepsy in young Tsc1(+/-) mice exhibits age-dependent expression that mimics that of human tuberous sclerosis complex.
1/2015	Analysis of vigabatrin treatment causing visual field defects in infantile spasms.
4/2011	Epilepsy: Vigabatrin treatment and visual field loss.
1/2010	Management of West syndrome in a patient with methylmalonic aciduria.
1/2009	Taurine deficiency is a cause of vigabatrin-induced retinal phototoxicity.
3/2007	Severe relapse of epilepsy after vigabatrin withdrawal: for how long should we treat symptomatic infantile spasms?
6/2006	Cryptogenic late-onset epileptic spasms: an overlooked syndrome of early childhood?

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Olivier Dulac Research Topics

Disease

30	Epilepsy (Aura) 01/2021 - 04/2002
24	Seizures (Absence Seizure) 01/2021 - 04/2002
12	Brain Diseases (Brain Disorder) 01/2019 - 02/2006
12	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2019 - 02/2008
7	Infantile Spasms (West Syndrome) 01/2019 - 03/2007
5	Status Epilepticus (Complex Partial Status Epilepticus) 01/2022 - 02/2006
5	Epileptic Syndromes 11/2014 - 03/2003
5	Drug Resistant Epilepsy 04/2009 - 03/2003
4	Body Weight (Weight, Body) 12/2017 - 05/2003
3	Spasm (Spasms) 10/2020 - 06/2006
3	Lennox Gastaut Syndrome 01/2019 - 11/2014
3	Pyridoxine-dependent epilepsy 12/2016 - 07/2010
3	Inborn Errors Metabolism (Inborn Errors of Metabolism) 02/2015 - 01/2010
3	Glycogen Storage Disease Type I 02/2015 - 11/2012
3	Hyperinsulinism (Hyperinsulinemia) 02/2015 - 10/2008
3	Fever (Fevers) 11/2012 - 10/2010
3	Absence Epilepsy (Childhood Absence Epilepsy) 12/2009 - 10/2006
2	Angelman Syndrome (Syndrome, Angelman) 01/2022 - 01/2019
2	Generalized Epilepsy with Febrile Seizures Plus 01/2019 - 07/2009
2	Menkes Kinky Hair Syndrome (Menkes Disease) 01/2013 - 08/2008
2	Encephalitis (Encephalitis, Rasmussen) 08/2011 - 03/2005
2	Partial Epilepsies (Epilepsy, Partial) 04/2009 - 06/2006
2	Idiopathic Generalized Epilepsy 10/2006 - 08/2002
2	Juvenile Myoclonic Epilepsy 10/2006 - 01/2003
1	Infantile Epileptic-Dyskinetic Encephalopathy 10/2020
1	Tuberous Sclerosis (Bourneville's Disease) 04/2016
1	Atrophy 04/2014
1	Microcephaly 04/2014
1	Anti-N-Methyl-D-Aspartate Receptor Encephalitis 12/2013
1	Congenital Hyperinsulinism 02/2013
1	Peroxisomal Disorders (Peroxisomal Disorder) 01/2013
1	Nonketotic Hyperglycinemia 01/2013
1	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2013
1	Vitamin B 6 Deficiency (Pyridoxine Deficiency) 01/2013
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2013
1	Sulfite oxidase deficiency 01/2013
1	Infections 11/2012
1	Ischemia 11/2012
1	Hypoxia (Hypoxemia) 11/2012
1	Hypoglycemia (Reactive Hypoglycemia) 11/2012
1	Lafora Disease 09/2011
1	Hallucinations (Hallucination) 08/2011
1	Febrile Seizures (Febrile Seizure) 04/2011
1	Inflammation (Inflammations) 01/2011

Drug/Important Bio-Agent (IBA)

13	Anticonvulsants (Antiepileptic Drugs)IBA 01/2019 - 04/2002
11	Vigabatrin FDA Link 01/2020 - 09/2002
7	Pharmaceutical PreparationsIBA 01/2021 - 09/2007
7	stiripentolIBA 01/2018 - 06/2006
5	Valproic Acid (Depakote)FDA LinkGeneric 06/2018 - 07/2010
5	SteroidsIBA 07/2015 - 09/2007
4	Immunoglobulin E (IgE)IBA 12/2009 - 08/2002
3	N-Methylaspartate (NMDA)IBA 01/2019 - 12/2012
3	gamma-Aminobutyric Acid (GABA)IBA 01/2019 - 08/2009
3	Fatty Acids (Saturated Fatty Acids)IBA 02/2015 - 11/2012
3	Adrenocorticotropic Hormone (ACTH)FDA Link 10/2007 - 09/2002
2	Sodium Channel BlockersIBA 10/2020 - 01/2019
2	Oxcarbazepine (Trileptal)FDA LinkGeneric 12/2017 - 11/2004
2	BenzodiazepinesIBA 01/2017 - 04/2011
2	Clobazam (HR 376)IBA 01/2016 - 05/2015
2	Adrenal Cortex Hormones (Corticosteroids)IBA 07/2015 - 08/2009
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 12/2013 - 08/2011
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2013 - 06/2008
2	Aminobutyrates (Aminobutyric Acid)IBA 08/2011 - 04/2011
2	Carbamazepine (Tegretol)FDA LinkGeneric 04/2011 - 06/2006
2	Phenobarbital (Luminal)FDA Link 04/2011 - 04/2011
2	Lamotrigine (Lamictal)FDA LinkGeneric 04/2011 - 01/2010
2	EnzymesIBA 07/2010 - 05/2006
2	CreatinineIBA 07/2010 - 05/2009
2	DNA (Deoxyribonucleic Acid)IBA 07/2010 - 03/2005
2	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2010 - 06/2006
2	Levetiracetam (Keppra)FDA LinkGeneric 05/2009 - 05/2003
2	Amino Acids FDA Link 01/2009 - 03/2005
2	Topiramate (Topamax)FDA LinkGeneric 11/2004 - 03/2003
1	Proteins (Proteins, Gene)FDA Link 01/2019
1	Glutamic Acid (Glutamate)FDA Link 12/2016
1	AsparagineIBA 12/2016
1	trans-sodium crocetinate (crocetin)IBA 04/2016
1	N-desmethylclobazam (norclobazam)IBA 05/2015
1	Blood Glucose (Blood Sugar)IBA 02/2015
1	rufinamide FDA Link 11/2014
1	glutaminyl-tRNA synthetaseIBA 04/2014
1	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA 04/2014
1	Qa-SNARE Proteins (Syntaxin)IBA 01/2014
1	Carrier Proteins (Binding Protein)IBA 01/2014
1	Leucovorin (Folinic Acid)FDA Link 01/2013
1	CeroidIBA 01/2013
1	Vitamin B 6IBA 01/2013
1	barbituric acid (barbiturate)IBA 01/2013
1	Hypoglycemic Agents (Hypoglycemics)IBA 11/2012
1	Lactic Acid (Lactate)FDA LinkGeneric 11/2012
1	polyglucosanIBA 09/2011
1	GlycogenIBA 09/2011
1	Oligoclonal BandsIBA 08/2011
1	ChloridesIBA 04/2011
1	K Cl- CotransportersIBA 04/2011
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2011

Therapy/Procedure

11	Therapeutics 01/2019 - 03/2003
6	Ketogenic Diet 01/2022 - 04/2009
1	Off-Label Use 03/2013
1	Electrodes (Electrode) 01/2012